Volume 5, Number 14 - 15, October - December, 2013

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The present work was aimed to formulate, Optimise &evaluate Self‐Micro Emulsifying Drug Delivery System (SMEDDS) of Amiodarone HCl and to evaluate its in vitro release. The main objective of formulation was dissolution enhancement. SMEDDS comprises of isotropic mixture of natural or synthetic oil (Capmul MCM C8), surfactant (Tween 80), and co surfactant (Propylene glycol), which upon dilution with aqueous media or in 0.1 N HCl spontaneously form fine o/w micro emulsion with less than 200 nm in droplet size. Solubility of Amiodarone HCl were determined in various vehicles. Ternary phase diagrams (1:1,1:2,2:1) were plotted to identify the efficient Self- Emulsification region with selected excipients. For optimisation, 22 full factorial design was applied. SMEDDS was investigated for Clarity (Transmittance), Phase Separation, Globule size with Shape, Zeta Potential, Effect of various Dilutions, Thermodynamic Stability and in vitro release of formulation. Dissolution study was compared with marketed tablet. The batch having 116.23±8.33 nm Globule Size, clear bluish (PDI 0.261±0.021), 96.52±0.52 Transmittance, 5.60 pH, 174 centipoise Viscosity & 36.1 mV Zeta Potential was optimized. The Dissolution efficiency of SMEDDS containing Amiodarone HCl & Marketed tablet was found to be 33.33% & 15.27% respectively, means SMEDDS having Dissolution Efficiency 2.18 times higher than Marketed Tablet. In Thermodynamic stability study, no phase separation or no precipitation, in Accelerated stability Study [40±2° C / 75 % RH±5%],there was no significant difference in Globule Size after 3 months. From ANOVA Result, It was found that Oil concentration having significant effect on droplet size (p value< 0.0001), (Ref: Dharmang Pandya, Janak Patel, Samir Patel. Formulation & development of self micro emulsifying drug delivery system (SMEDDS) containing AMIODARONE HCL for dissolution enhancement. Discovery Pharmacy, 2013, 5(14), 6-12).

RESEARCH

Formulation & development of self micro emulsifying drug delivery system (SMEDDS) containing AMIODARONE HCL for dissolution enhancement


Dharmang Pandya, Janak Patel, Samir Patel

The present work was aimed to formulate, Optimise &evaluate Self‐Micro Emulsifying Drug Delivery System (SMEDDS) of Amiodarone HCl and to evaluate its in vitro release. The main objective of formulation was dissolution enhancement. SMEDDS comprises of isotropic mixture of natural or synthetic oil (Capmul MCM C8), surfactant (Tween 80), and co surfactant (Propylene glycol), which upon dilution with aqueous media or in 0.1 N HCl spontaneously form fine o/w micro emulsion with less than 200 nm in droplet size. Solubility of Amiodarone HCl were determined in various vehicles. Ternary phase diagrams (1:1,1:2,2:1) were plotted to identify the efficient Self-Emulsification region with selected excipients. For optimisation, 22 full factorial design was applied. SMEDDS was investigated for Clarity (Transmittance), Phase Separation, Globule size with Shape, Zeta Potential, Effect of various Dilutions, Thermodynamic Stability and in vitro release of formulation. Dissolution study was compared with marketed tablet. The batch having 116.23±8.33 nm Globule Size, clear bluish (PDI 0.261±0.021), 96.52±0.52 Transmittance, 5.60 pH, 174 centipoise Viscosity & 36.1 mV Zeta Potential was optimized. The Dissolution efficiency of SMEDDS containing Amiodarone HCl & Marketed tablet was found to be 33.33% & 15.27% respectively, means SMEDDS having Dissolution Efficiency 2.18 times higher than Marketed Tablet. In Thermodynamic stability study, no phase separation or no precipitation, in Accelerated stability Study [40±2° C / 75 % RH±5%],there was no significant difference in Globule Size after 3 months. From ANOVA Result, It was found that Oil concentration having significant effect on droplet size (p value< 0.0001).

Discovery Pharmacy, 2013, 5(14), 6-12

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RESEARCH

Studies on Structural and Biological Aspects of Transition Metal Complexes of the Ligand 2- Amino -4-(P-Hydroxy Phenyl) Thiazole


Dinkar Malik, Punam Yadav, Sandeep Kumar, Vijai Malik

Metal complexes of the type ML2X2 (where M = Cu (II), Co (II) and Ni (II), L= 2-amino-4-(p-hydroxy phenyl)thiazole and X= cl-, CH3COO-) were prepared and characterized with the help of their elemental analysis, IR, electronic and magnetic susceptibility studies. IR studies have shown that nitrogen of the amino group and sulphur of the thiazole ring took part in coordination. Magnetic and electronic spectral studies have shown that all the complexes are having octahedral geometry. These newly synthesized complexes were also screened for their antifungal activity against different fungi at different concentrations. The activity decreases with decrease of concentration and the metal complexes are less toxic than the parent ligand.

Discovery Pharmacy, 2013, 5(15), 15-17

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