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Backgroud: Hypocoagulable state and, or haemophilia can cause death due to excessive blood loss from minor trauma, post partum haemorrhage, motor traffic accidents or surgical incision. Jatropha curcas is a medicinal plant used by traditional medicine healers in treatment of fresh wound/cuts, post partum heamorrhage, bleeding from umbilical stump and as a purgative. Aim: To carry out some in-vivo and in-vitro haemostatic studies on Jatropha curcas in rats and to scientifically demonstrate its possible coagulant activity. Methods: The leaves of Jatropha curcas were harvested, air dried, ground and macerated in equal volumes of water and ethanol for 24hours. Sieved separately, filtered using Whatman filter paper and evaporated to dryness. The phytochemistry and acute toxicity testing were done. Adult white Wistar rats of average weight of 110grams were divided into cages of 5 animals per cage and housed in a standard animal house for one week acclimatization. Extracts of Jatropha curcas were orally administered daily for four weeks. Tail bleeding was used for bleeding time while whole blood clotting time, platelet count, prothrombin and activated partial thromboplastin time were done on whole blood collected through orbital sinus. All samples where necessary, were sent to the Laboratory as soon as collected. Data collected were statistically analysed with SPSS version 16 and P.Values ≤ 0.5 were considered as significant (Ref: Azikiwe CCA, Ifezulike CC, Amazu LU, Nwabali MO. Haemostatic activities of Jatropha curcas (Linn) in rats. Drug Discovery, 2014, 8(19), 16-20), (Image: farm4.staticflickr.com).

DRUG DISCOVERY OF THE MONTH

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Discovery of novel vaccine for Malaria

Brithvi V

Scientists from Singapore's Nanyang Technological University (NTU) have discovered a key process during the invasion of the blood cell by the Malaria parasite, and found a way to block this invasion. According to the World Health Organisation, about 3.3 billion people are at risk of Malaria. To prevent this invasion, Prof Preiser's research team developed antibodies which can interfere with this invasion process. The team outcome was made possible with the development of a new screening assay that allows the rapid characterization of parasite signalling, which is significantly faster than conventional methods. The newly invented technique utilises a high-throughput fluorescence scanning approach if antibodies or drugs fail to prevent the invasion of the red blood cell by the malaria parasites, the sample will light up.

Drug Discovery, 2014, 8(19), 7-8

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FDA APPROVED DRUGS

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FDA approved drugs – October 2013

Brithvi V

DUAVEE (CONJUGATED ESTROGENS/BAZEDOXIFENE)
Company
Pfizer; Approved by October 2013
Treatment Area
Vasomotor symptoms associated with menopause and postmenopausal osteoporosis

Drug Discovery, 2014, 8(19), 9-12

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FDA approved drugs – November 2013

Brithvi V

OLYSIO (SIMEPREVIR)
Company
Janssen Therapeutics; Approved by November 2013
Treatment Area
Hepatitis C

Drug Discovery, 2014, 8(19), 13-15

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RESEARCH

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Haemostatic activities of Jatropha curcas (Linn) in rats

Azikiwe CCA, Ifezulike CC, Amazu LU, Nwabali MO

Hypocoagulable state and, or haemophilia can cause death due to excessive blood loss from minor trauma, post partum haemorrhage, motor traffic accidents or surgical incision. Jatropha curcas is a medicinal plant used by traditional medicine healers in treatment of fresh wound/cuts, post partum heamorrhage, bleeding from umbilical stump and as a purgative. To carry out some in-vivo and in-vitro haemostatic studies on Jatropha curcas in rats and to scientifically demonstrate its possible coagulant activity.

Drug Discovery, 2014, 8(19), 16-20

Full Text | PDF