Volume 3, Number 7-9, April - June, 2013

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About the Cover

Two men died after being infected with a type of bird flu never before been seen in humans, China reported on March 31. The two Shanghai men, 87 and 27 years old, contracted the H7N9 virus in February and died within 8 days. A 35-year-old woman from Anhui province, who contracted it in March, is now in critical condition. The path of transmission of the three cases is not clear. The younger woman reportedly had contact with birds, and the 27-year-old man and younger woman were both butchers. After examining 88 close contacts with the infected, China’s CDC has concluded that the virus is not passing between humans. But two sons of one of those confirmed to have an H7N9 infection also suffered acute pneumonia, and one died. The cause is yet unknown, but health authorities are calling the cluster of severe pneumonia worrisome (Source: blogs.nature.com/news), (Image: www.nation.com.pk).

DISEASE OF THE MONTH

Leishmaniasis: a perception on Neglected Tropical Disease

Balasubramanian J, Narayanan N

Leishmaniasis is a parasitic illness that is discovered in areas of the tropics, subtropics, and southeast European countries. It is categorized as Neglected Tropical Disease (NTD). Leishmaniasis is brought on by disease with Leishmania harmful bacteria, which are distribute by the chew of phlebotomine sand flies. There are several different types of leishmaniasis in community. The most typical types are cutaneous leishmaniasis, which causes skin blisters, and deep leishmaniasis, which impacts several areas (usually spleen, liver organ, and cuboid marrow).

Disease, 2013, 3(7), 3-4

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RESEARCH

Inter-arm systolic blood pressure difference is associated with a higher incidence of ischemic strokes

Shashi K. Agarwal

Inter-arm systolic blood pressure difference (IAD) of more than 15 mm Hg (SIAD) is associated with increased cardiovascular morbidity and mortality. IAD is attributed to atherosclerosis of the upper arm arteries. Although suggested in the literature, it has never been objectively documented that this group of patients are at a higher risk of strokes. This study was done to see if an association exists between SIAD and strokes.

Disease, 2013, 3(7), 5-6

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RESEARCH

Assessment of dietary pattern among coronary heart disease outpatients who attended El-Shaap teaching hospital, Khartoum state


Maher MA, Gutbi SS

This study is an observational complete-coverage, hospital-based study. Focusing on the assessment of the dietary pattern among Sudanese coronary heart disease outpatients, who attended El-Shaap Teaching Hospital, Khartoum State, during the period from July 2011 to February 2012. The primary data were collected using questionnaire survey, food frequency questionnaire and 24-hour food recall were used to interviews 72 respondents. Secondary data were obtained from books, news papers, previous published and non published research, online papers and articles.

Disease, 2013, 3(7), 7-14

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RESEARCH

Seroprevalence of hepatitis B virus markers in patients attending to a tertiary care hospital in Kanchipuram, India


Sandhya BK, Apurba SS, Senthamarai S, Sivasankari S, Kumudavathi MS, Anitha C, Amshavathani SK

Hepatitis B virus (HBV) infection is a global public health problem. It is the most common cause of chronic liver disease, including cirrhosis of the liver and hepatocellular carcinoma worldwide. Considering this disease burden caused by HBV infection, this study was undertaken to estimate the seroprevalence rate of various HBV markers in our tertiary care hospital

Disease, 2013, 3(7), 15-17

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DISEASE OF THE MONTH

McCune-Albright syndrome (MAS): a perspective

Balasubramanian J, Narayanan N

The McCune-Albright syndrome (MAS) is a rare, sporadic diseased characterized by a classical triad of clinical signs: polyostotic fibrous dyslpasia, skin hyperpigmentation and endocrine dysfunction. The disease is caused by postzygotic, somatic mutations at codon 201 of the GNAS1 gene that results in cellular mosaicism, thus leading to a broad spectrum of clinical manifestations. The major endocrine disorders include autonomous hyperfunction of several endocrine glands, such as gonads, thyroid, pituitary and adrenal cortex, i.e. glands sensitive to trophic agents acting through cAMP dependent pathway. Since specific treatment is required, the prognosis depends on the severity of each individual endocrine and non-endocrine manifestation. As mutation detection rates may vary considerably according to the type of tissue analyzed and the detection method used, sensitive and specific molecular methods must be used to look for the mutation from all available affected tissues and from easily accessible tissues, particularly in the presence of atypical and monosymptomatic forms of MAS. This review will briefly summarize the clinical manifestations and the most recent data on genetics and molecular diagnostic of the disease.

Disease, 2013, 3(8), 20-21

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RESEARCH

Prediabetes in Hypertensive Patients: A Common and Dangerous Co-morbidity

Shashi K. Agarwal

Hypertension and diabetes are common medical disorders, and frequently co-exist. Both conditions increase cardiovascular events. Recent studies have recognized that non-diabetic dysglycemia, or prediabetes, is more prevalent than diabetes. Prediabetic dysglycemia may be present in many patients for several years prior to the development of overt diabetes. Like diabetes, it increases the risk for cardiovascular events. The association of hypertension with prediabetes is therefore not benign. Aggressive life style changes and targeted treatment of both conditions is mandatory to reduce the higher cardiovascular morbidity and mortality seen in these patients.

Disease, 2013, 3(8), 22-25

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DISEASE OF THE MONTH

Biggest Genetic Sequencing analysis of Human Disease

Balasubramanian J

Many common diseases, including cardiovascular disease, cancer, and various psychiatric illnesses, arise from complex interactions between a person’s genetics and all the environmental influences he or she encounters over a lifetime. If we untangle these factors and determine the underlying causes, we might better prevent, diagnose, and treat the diseases.

Disease, 2013, 3(9), 28

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RESEARCH

Seroprevalence of toxoplasmosis in pregnant women with bad obstetric history in a tertiary care hospital, Kanchipuram - a pilot study


Senthamarai S, Sivasankari S, Apurba SS, Sandhya BK, Kumudavathi MS, Anitha C, Amshavathani SK

Toxoplasmosis can cause significant morbidity and mortality in the developing fetus if the pregnant mother gets acute infection during pregnancy. Early diagnosis of toxoplasmosis is essential to start appropriate treatment on time to reduce the transplacental transmission to fetus. In India the seroprevalence for toxoplasmosis varies between 5% and 46.7%.

Disease, 2013, 3(9), 29-32

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