Volume 1, Number 2, April - June, 2015

Table of Contents

Previous | Next

About the Cover

Phenytoin (imidazolidinedione derivatives) is a major antiepileptic drug. These analogs were investigated for different types of biological activities such as antiepileptic, antiinflammtory, antibacterial, antioxidant, antidiabetic and other anticipated biological activities. Regarding the significance of phenytoin, it was synthesize it from the easily accessible starting materials either synthetic or natural. A convenient synthesis of phenytoin analogues prepared from the condensation between benzil and urea and then converted to the desired derivatives by condensation with aryl compounds. This article provides useful clues for further design and discovery of biologically active imidazolidinedione agents (Ref: Mohammad Asif. Biological Activities of Phenytoin and Related Compounds. Discovery Chemistry, 2015, 1(2), 55-63), (Image: https://www.youtube.com/watch?v=_dhQC98WPzw)

PERSPECTIVE

Biological Activities of Phenytoin and Related Compounds

Mohammad Asif

Phenytoin (imidazolidinedione derivatives) is a major antiepileptic drug. These analogs were investigated for different types of biological activities such as antiepileptic, antiinflammtory, antibacterial, antioxidant, antidiabetic and other anticipated biological activities. Regarding the significance of phenytoin, it was synthesize it from the easily accessible starting materials either synthetic or natural. A convenient synthesis of phenytoin analogues prepared from the condensation between benzil and urea and then converted to the desired derivatives by condensation with aryl compounds. This article provides useful clues for further design and discovery of biologically active imidazolidinedione agents.

Discovery Chemistry, 2015, 1(2), 55-63

Full Text | PDF