Volume 1, Number 1, January - March, 2015

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About the Cover

Green chemistry is the new and rapid emerging branch of chemistry. The beginning of green chemistry is considered as a response to the need to reduce the damage of the environment by man-made materials and the processes used to produce them. Green chemistry could include anything from reducing waste to even disposing of waste in the correct manner. All chemical wastes should be disposed of in the best possible manner without causing any damage to the environment and living beings. The green chemistry revolution is providing an enormous number of challenges to those who practice chemistry in industry, education and research. With these challenges however, there are an equal number of opportunities to discover and apply new chemistry, to improve the economics of chemical manufacturing and to enhance the much-tarnished image of chemistry. This article presents selected examples of implementation of green chemistry principles in everyday life (Ref: Goyal Anju, Saini Vandana, Arora Sandeep. Green chemistry: a new approach towards science. Discovery Chemistry, 2015, 1(1), 5-17), (Image: www.iatp.org).

ANALYSIS

Water quality and pollution status of Upper Lake, Bhopal (MP)

Asita Singh, Pandey SC, Borana K

Upper Lake is a freshwater lake, which is the major source of drinking water in the city of Bhopal, the capital city of M.P., the central province of India, but due to anthropogenic activities this lake is being polluted. During the investigation physicochemical parameters were analyzed to determine the water quality of Upper Lake monthly in the year 2010.

Discovery Chemistry, 2015, 1(1), 1-4

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ANALYSIS

Green chemistry: a new approach towards science

Goyal Anju, Saini Vandana, Arora Sandeep

Green chemistry is the new and rapid emerging branch of chemistry. The beginning of green chemistry is considered as a response to the need to reduce the damage of the environment by man-made materials and the processes used to produce them. Green chemistry could include anything from reducing waste to even disposing of waste in the correct manner. All chemical wastes should be disposed of in the best possible manner without causing any damage to the environment and living beings. The green chemistry revolution is providing an enormous number of challenges to those who practice chemistry in industry, education and research. With these challenges however, there are an equal number of opportunities to discover and apply new chemistry, to improve the economics of chemical manufacturing and to enhance the much-tarnished image of chemistry. This article presents selected examples of implementation of green chemistry principles in everyday life.

Discovery Chemistry, 2015, 1(1), 5-17

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ANALYSIS

Recent advancement of potentially significant Triazole derivatives

Mohammad Asif

Heterocyclic compounds analogues have attracted strong interest due to their useful pharmacological properties. Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. The small triazole nucleus is present in various compounds that possess various types of biological activities, such as, anti-microbial, antibacterial, antifungal, antiviral, anti-malarial, anti-tumor, anthelmintic, antileishmanial, anticonvulsant, antidepressant, antihypertensive, analgesic, antiinflammatory and hypoglycemic properties. Scientists develop a lot of new compounds related to this moiety and screened them for their different pharmacological activities to get a molecule which have good pharmacological activity and lesser side effect. This reviews attempted the various developments in biological activities of triazole derivatives.

Discovery Chemistry, 2015, 1(1), 18-32

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ANALYSIS

Recent Advances in the Development of Salicylic Acid Analogues as Anti-Tubercular Agents

Mohammad Asif

Tuberculosis is still the second most crucial infectious disease globally. The effective treatment of tuberculosis is difficult due to the unusual cell wall structure and composition of mycobacteria, which makes many drugs ineffective and obstructs the entrance of drugs. The most essential cause for this is drug resistant tuberculosis, persistent infection and synergism of tuberculosis with HIV and also no any new effective chemical entity has come in last few decades. The modern drug design promises to bring significant development in the fight against tuberculosis. In this review, brief discuss on salicylic acid derivatives as anti-tubercular agent.

Discovery Chemistry, 2015, 1(1), 33-36

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RESEARCH

Synthesis, characterization and study of electrical conductivity of newly synthesized 1-N-4-SAHDF-Resin-III

Nagmote M, Dontulwar J, Singru R

A terpolymer 1-N-4-SAHDF-Resin-III was synthesized from 1-Naphthol-4-sulphonic acid and Hexamethylene diamine with formaldehyde by polycondenssation method in an acidic medium with molar proportion of reactants (3:1:4). To reveal the structure of the resin, the resin was characterized by elemental analysis and a spectral method, i.e. composition of terpolymer has been determined on the basis of its elemental analysis. The terpolymer resin has been characterized by FT-IR and NMR (1H & 13C) spectra and by SEM. The DC conductivity of sample was determined by four probe method. The conductivity of 1-N-4-SAHDF-Resin-III was found to be in the range of 4.95 x 10-7 to 1.428 x 10-4 ohm- 1cm-1 in the temperature range 313K-433K. The activation energy of the conduction for 1-N-4-SAHDF-Resin-III was found to be 1.054 x 10-20 J/K.

Discovery Chemistry, 2015, 1(1), 37-45

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PERSPECTIVE

Extraction of Eugenol from Ocimum sanctum and its Therapeutic applications

Prabhu Sekar, Raghu Thirumalai, Aswin Thanush

Ocimum sanctum Linn (Tulsi) is one of the common herbs for its various medicinal applications. Eugenol is the important ingredients found in tulsi. It is said to be possess various biological properties such as antioxidant, antimutagenic and anti-inflammatory effects, etc. Recent studies showed the anticancer activity of eugenol against various cancer cell lines and animal models. Eugenol has evolved as a promising candidate both in in vivo and in vitro studies.

Discovery Chemistry, 2015, 1(1), 46-48

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PERSPECTIVE

Anti-tubercular Potential of Ethylenediamine Derivatives: A Short Review

Mohammad Asif

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Control of TB is complicated by the long-course therapy regimens, the incapability to eliminate latent organisms, and the increasing appearance of multidrug resistant strains of M. tuberculosis. New drugs for the prevention of TB are urgently required, including developments of new drug regimens to minimize the emergence of drug resistance, to treat MDR-TB patients and to eliminate the latent bacteria. Recent years, many new structural classes of anti-TB agents are come out, some of which exhibit promising activities against vulnerable and resistant strains of M. tuberculosis. In particular, the newly discovered ethylenediamine derivatives with significant anti-TB activity and generated considerable excitement.

Discovery Chemistry, 2015, 1(1), 49-54

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