Volume 6, Number 15, Pages 1-15, January - March, 2015

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In the present study, aqueous methanolic extract of Bilimbi and aqueous acetone extract of Star fruit were assessed for its anthelminthic activity against adult e arthworms (Pheretima posthuma). Various concentrations of both extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Albendazole was used as a reference standard. The result revealed that the bilimbi fruit extract was more effective compared to the standard and star fruit extract with 30.50 and 47 minutes for paralysis and death respectively at the concentration of 100mg/ml, that of standard and star fruit was 34.32 and 48.00 and 40.60 and 57.30 minutes for paralysis and death respectively. The comparative study showed that out of the two, bilimbi fruit extract proves to be a better anthelmintic remedy (Ref: Jyoti Bala Chauhan, Wethroe Kapfo, Gulnaz AR. In vitro comparative study of Bilimbi and Star fruit extracts for Anthelmintic activity. Discovery Biotechnology, 2014, 6(15), 5-8).

REVIEW

Stem cells research and applications - a ray of hope for chronic degenerating diseases

Jahan Ara M, Sailaja K

Stem cells are unique cells in the human body that can be described as ‘shape shifters’. These cells have the ability to change into other types of cells stem cells are found in the early embryo, the foetus, amniotic fluid, the placenta and umbilical cord blood stem cells are responsible for generating new tissues and once growth is complete, stem cells are responsible for repair and regeneration of damaged and ageing tissues. Applications of stem cells is their ability to differentiate into specific cell types, neuronal cells are of great interest for medical treatment of neurodegenerative diseases and traumatic injuries of CNS induced pluripotent stem cells are valuable aids in the study of disease development and drug treatment and they may have future uses in transplantation medicine. Further research is needed regarding the development and use of these cells.

Discovery Biotechnology, 2015, 6(15), 1-4

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RESEARCH

In vitro comparative study of Bilimbi and Star fruit extracts for Anthelmintic activity

Jyoti Bala Chauhan, Wethroe Kapfo, Gulnaz AR

In the present study, aqueous methanolic extract of Bilimbi and aqueous acetone extract of Star fruit were assessed for its anthelminthic activity against adult e arthworms (Pheretima posthuma). Various concentrations of both extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Albendazole was used as a reference standard. The result revealed that the bilimbi fruit extract was more effective compared to the standard and star fruit extract with 30.50 and 47 minutes for paralysis and death respectively at the concentration of 100mg/ml, that of standard and star fruit was 34.32 and 48.00 and 40.60 and 57.30 minutes for paralysis and death respectively. The comparative study showed that out of the two, bilimbi fruit extract proves to be a better anthelmintic remedy.

Discovery Biotechnology, 2015, 6(15), 5-8

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ANALYSIS

High nuclease activity shown by sorghum tissue in vitro

Sunitha EM, RAjani A, Ulaganathan K

Lack of suitable genetic transformation protocol is the major bottleneck for application of transgenic approach for sorghum improvement. Available evidence from the literature and our work shows that tissue culture methodology for plant regeneration is not a limitation for the development of transgenics in sorghum. However, the block lies in the transformation process itself. In this paper we report the presence of very high levels of extra cellular and intra cellular nuclease activities which may be responsible for the poor transformation competence of the sorghum tissue. Further we report treatments that can mitigate the nuclease activity without affecting the tissue culture competence of the tissue.

Discovery Biotechnology, 2015, 6(15), 9-15

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