Volume 2, Number 3 - 5, January - March, 2013

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About the Cover

Vesicular arbuscular mycorrhiza (VAM is the most abundant kind of mycorrhiza described as a universal plant symbosis. VAM fungi have been regarded as a boon for agriculture, forestry and restoration of disturbed ecosystems. Gerdemann’s students, Rhodes (1980) were in a prescient review of the benefits of AM fungi in agricultural systems that ‘root pathogens should in most instances be regarded as pathogens of mycorrhizae, since it is the mycorrhizal root that is encountered by pathogens in most cases. Pathogenic microorganisms have coevolved with VA fungi and have been exposed to the mycorrhizal condition of roots over thousands of centuries. Effectiveness of dual inoculation with diazotrophs and VAM fungi on growth and medicinal compounds of examined by Saleh et al. (1998). A field experiment was established to evaluate the effect of inoculation with a mixture of Azotobacter, Azospirillum and Brandy-rhizobium and/ or vesicular – arbuscular mycorrhiza on the growth and alkaloid content of the medicinal plant (Ref: Porkodi et al. Vesicular arbuscular fungal association with medicinal plants, Discovery Biotechnology, 2013, 2(5), 19-22), (Images: http://www.ufz.de, http://media-1.web.britannica.com).

BIOTECHNOLOGY OF THE MONTH

Combinatorial Chemistry – a bottleneck in Drug discovery

Balasubramanian J, Azhageshraj K

Combinatorial chemistry is an innovative method of synthesizing many different substances quickly and at the same time. Combinatorial chemistry contrasts with the time-consuming and labor intensive methods of traditional chemistry where compounds are synthesized individually, one at a time. CombiChem is used to synthesize large number of chemical compounds by combining sets of building blocks. Each newly synthesized compound's composition is slightly different from the previous one. A traditional chemist can synthesize 100-200 compounds per year. A combinatorial robotic system can produce in a year thousands or millions compounds which can be tested for potential drug candidates in a high-throughput screenin process.

Discovery Biotechnology, 2013, 2(3), 3-5

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BIOTECHNOLOGY OF THE MONTH

The Stem Cell Research and its Technology

Balasubramanian J, Narayanan N

Stem cell technology or SC is a new technology that takes human cells and develops new cells of any of the 220 varieties that are present in our bodies. The cells used in this technology include those in our blood and brain. The stem cell technology uses the tissue found in our bone marrow to treat diseases like leukemia, cancer, Parkinson and several others. Stem cell technology helps in getting rid of chronic diseases and is been proved as one of the safest methods to treat ailments. Stem cell technology is indeed here to stay and is sure to cure many ailments. Stem cell technology is definitely a break-through in medical science.

Discovery Biotechnology, 2013, 2(4), 8-9

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BIOTECHNOLOGY OF THE MONTH

A Review on premise and perceptions of Nanomedicine

Balasubramanian J, Narayanan N

Over the past few decades, our knowledge on the aetiology of cancer has increased exponentially. This improved understanding of the processes that are at the heart of malignant transformation and tumorigenesis has resulted in the development of several new classes of antitumour therapeutics.

Discovery Biotechnology, 2013, 2(5), 12-13

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RESEARCH

Ontogeny, tissue specificity and mRNA expression changes in angiotensinogen gene upon Aeromonas Hydrophila infection in Puntius Sarana


Das A, Sahoo PK

Angiotensinogen (AGT), an acute phase protein and its expression increases during inflammation. Being a constituent of Renin-Angiotensin System (RAS), AGT helps in vascular permeability, leukocyte infiltration and tissue proliferation.

Discovery Biotechnology, 2013, 2(5), 14-18

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RESEARCH

Vesicular arbuscular fungal association with medicinal plants

Porkodi M, Sampathkumar G

Vesicular arbuscular mycorrhiza (VAM is the most abundant kind of mycorrhiza described as a universal plant symbosis. VAM fungi have been regarded as a boon for agriculture, forestry and restoration of disturbed ecosystems

Discovery Biotechnology, 2013, 2(5), 19-22

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RESEARCH

In vitro micropropagation of Phyla Nodiflora (Linn.) Greene a native medicinal plant

Balaji P, Ebenezer GAI

Phyla nodiflora L. is a well known native medicinal plant in Indian systems of medicine. Explants of shoots with nodal region with and without the axillary bud were cultured on MS medium supplemented with PGRs

Discovery Biotechnology, 2013, 2(5), 23-28

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